A new cannabis compound that appears to have “remarkable antioxidant and skin anti-inflammatory” properties has been discovered by scientists.
The isolated cannabinoid, classified as cannabizetol (CBGD), shows promise for the expanding base of knowledge regarding the therapeutic and medicinal potential of the marijuana plant.
Cannabizetol is formed when two cannabinoid molecules bind together with a methylene bridge, the researchers explained in a new paper. Aside from its promising medical findings, cannabizetol is also one of the rare compounds in a class known as dimeric cannabinoids, one of only four dimeric molecules currently identified in cannabis.
A new cannabis compound that appears to have “remarkable antioxidant and skin anti-inflammatory” properties has been discovered by scientists.
The isolated cannabinoid, classified as cannabizetol (CBGD), shows promise for the expanding base of knowledge regarding the therapeutic and medicinal potential of the marijuana plant.
Cannabizetol is formed when two cannabinoid molecules bind together with a methylene bridge, the researchers explained in a new paper. Aside from its promising medical findings, cannabizetol is also one of the rare compounds in a class known as dimeric cannabinoids, one of only four dimeric molecules currently identified in cannabis.
“We demonstrate that cannabizetol exhibits remarkable antioxidant and skin anti-inflammatory activity, significantly higher than that observed for the known dimeric cannabinoid cannabitwinol,” the study says.
The Italian and Swiss authors, writing in the September 2025 issue of the peer-reviewed Journal of Natural Products, said their results “suggest that among the many still unknown cannabinoids there are also methylene-bridged dimers of other cannabinoids, including dimers composed of two different cannabinoids, with potential biological activities of great interest.”
“The synthesis of analytical standards could be useful in facilitating the identification of these compounds in cannabis extracts,” they wrote—adding that “natural dimeric compounds are of considerable importance, as they enable further exploration of chemical space, potentially leading to novel biological activities beyond those of their respective monomers.”
The researchers used a number of inflammatory genes to test against CBGD. After a six-hour treatment, “the anti-inflammatory activity of the molecules was evaluated on 84 inflammatory genes using an RT-PCR array (RT2 Profiler PCR Array Human Inflammatory Cytokines and Receptors, QIAGEN S.r.l., Hilden, Germany), as previously described” they wrote.
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